HMSPCI complexes {apComplex}R Documentation

HMSPCI data complex estimates

Description

Affiliation matrices with rows corresponding to proteins and columns corresponding to complexes.

Usage

data(MBMEcHMSPCI)
data(SBMHcHMSPCI)
data(UnRBBcHMSPCI)

Details

These are the results from an analysis of the HMS-PCI data (Ho et al., 2002) using the Protein Complex Membership Graph (PCMG) algorithm proposed by Scholtens and Gentleman (2004). These estimates were constructed using a sensitivity parameter of .75, specificity of .99, and external data based on Gene Ontology cellular component annotation.

MBMEcHMSPCI contains multi-bait-multi-edge complex estimates. SBMHcHMSPCI contains single-bait-multi-hit complex estimates. UnRBBcHMSPCI contains unreciprocated bait-bait complex estimates.

Source

Scholtens, D. and Gentleman, R. Making sense of high throughput protein-protein interaction data. (2004).

References

Ho, et al. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415, 180-183 (2002).

Examples

data(MBMEcHMSPCI)

[Package apComplex version 1.0.1 Index]