GSE44104 {MetaGxOvarian} | R Documentation |
Biomarkers that predict disease progression might assist the development of better therapeutic strategies for aggressive cancers, such as ovarian cancer. Here, we investigated the role of collagen type XI alpha 1 (COL11A1) in cell invasiveness and tumor formation and the prognostic impact of COL11A1 expression in ovarian cancer. Microarray analysis suggested that COL11A1 is a disease progression-associated gene that is linked to ovarian cancer recurrence and poor survival. Small interference RNA-mediated specific reduction in COL11A1 protein levels suppressed the invasive ability and oncogenic potential of ovarian cancer cells and decreased tumor formation and lung colonization in mouse xenografts. A combination of experimental approaches, including real-time RT-PCR, casein zymography and chromatin immunoprecipitation (ChIP) assays, showed that COL11A1 knockdown attenuated MMP3 expression and suppressed binding of Ets-1 to its putative MMP3 promoter-binding site, suggesting that the Ets-1-MMP3 axis is upregulated by COL11A1. Transforming growth factor (TGF)-beta (TGF-??1) treatment triggers the activation of smad2 signaling cascades, leading to activation of COL11A1 and MMP3. Pharmacological inhibition of MMP3 abrogated the TGF-??1-triggered, COL11A1-dependent cell invasiveness. Furthermore, the NF-YA-binding site on the COL11A1 promoter was identified as the major determinant of TGF-??1-dependent COL11A1 activation. Analysis of 88 ovarian cancer patients indicated that high COL11A1 mRNA levels are associated with advanced disease stage. The 5-year recurrence-free and overall survival rates were significantly lower (P=0.006 and P=0.018, respectively) among patients with high expression levels of tissue COL11A1 mRNA compared with those with low expression. We conclude that COL11A1 may promote tumor aggressiveness via the TGF-??1-MMP3 axis and that COL11A1 expression can predict clinical outcome in ovarian cancer patients.
experimentData(eset): Experiment data Experimenter name: Wu Y, Chang T, Huang Y, Huang H, Chou C Laboratory: Wu, Chou 2013 Contact information: Title: COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer. URL: PMIDs: 23934190 Abstract: A 260 word abstract is available. Use 'abstract' method. Information is available on: preprocessing notes: platform_title: [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array platform_shorttitle: Affymetrix HG-U133Plus2 platform_summary: hgu133plus2 platform_manufacturer: Affymetrix platform_distribution: commercial platform_accession: GPL570 platform_technology: in situ oligonucleotide version: 2015-09-22 20:02:05 featureData(eset): An object of class 'AnnotatedDataFrame' featureNames: 1007_s_at 1053_at ... AFFX-HUMISGF3A/M97935_MB_at (42447 total) varLabels: probeset gene EntrezGene.ID best_probe varMetadata: labelDescription
assayData: 42447 features, 60 samples Platform type: --------------------------- Available sample meta-data: --------------------------- alt_sample_name: Tc_113 Tc_48 Tc_49 Tc_51 Tc_56 Tc_59 Tc_61 Tc_63 Tc_64 Tc_65 Tc_74 1 1 1 1 1 1 1 1 1 1 1 Tc_94 Te_69 Te_77 Te_78 Te_79 Te_84 Te_87 Te_89 Te_90 Te_91 Te_92 1 1 1 1 1 1 1 1 1 1 1 Te_93 Tm_101 Tm_102 Tm_106 Tm_107 Tm_110 Tm_95 Tm_96 Tm_97 Tm_98 Ts_11 1 1 1 1 1 1 1 1 1 1 1 Ts_14 Ts_15 Ts_17 Ts_19 Ts_2 Ts_20 Ts_21 Ts_23 Ts_24 Ts_26 Ts_28 1 1 1 1 1 1 1 1 1 1 1 Ts_3 Ts_31 Ts_32 Ts_34 Ts_35 Ts_36 Ts_37 Ts_39 Ts_4 Ts_41 Ts_43 1 1 1 1 1 1 1 1 1 1 1 Ts_45 Ts_46 Ts_47 Ts_5 Ts_8 1 1 1 1 1 sample_type: tumor 60 histological_type: clearcell endo mucinous ser 12 11 9 28 summarystage: early late 25 35 tumorstage: 1 2 3 4 17 8 30 5 recurrence_status: norecurrence recurrence 40 20 os_binary: long short 44 16 relapse_binary: long short 40 20 batch: 2010-09-07 2010-09-08 2010-10-14 2010-12-10 2010-12-14 20 2 18 16 4 uncurated_author_metadata: title: Tc_113///geo_accession: GSM1078972///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: clear cell///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tc_48///geo_accession: GSM1078973///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: clear cell///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tc_49///geo_accession: GSM1078974///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: clear cell///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tc_51///geo_accession: GSM1078975///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: clear cell///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tc_56///geo_accession: GSM1078976///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: clear cell///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tc_59///geo_accession: GSM1078977///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: clear cell///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tc_61///geo_accession: GSM1078978///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: clear cell///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tc_63///geo_accession: GSM1078979///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: clear cell///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tc_64///geo_accession: GSM1078980///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: clear cell///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tc_65///geo_accession: GSM1078981///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: clear cell///characteristics_ch1.2: advanced disease stage: stage II///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tc_74///geo_accession: GSM1078982///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: clear cell///characteristics_ch1.2: advanced disease stage: stage IV///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tc_94///geo_accession: GSM1078983///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: clear cell///characteristics_ch1.2: advanced disease stage: stage IV///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Te_69///geo_accession: GSM1078984///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: endometrioid///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Te_77///geo_accession: GSM1078985///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: endometrioid///characteristics_ch1.2: advanced disease stage: stage II///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Te_78///geo_accession: GSM1078986///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: endometrioid///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Te_79///geo_accession: GSM1078987///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: endometrioid///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Te_84///geo_accession: GSM1078988///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: endometrioid///characteristics_ch1.2: advanced disease stage: stage II///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Te_87///geo_accession: GSM1078989///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: endometrioid///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Te_89///geo_accession: GSM1078990///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: endometrioid///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Te_90///geo_accession: GSM1078991///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: endometrioid///characteristics_ch1.2: advanced disease stage: stage IV///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Te_91///geo_accession: GSM1078992///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: endometrioid///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Te_92///geo_accession: GSM1078993///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: endometrioid///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Te_93///geo_accession: GSM1078994///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: endometrioid///characteristics_ch1.2: advanced disease stage: stage II///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tm_101///geo_accession: GSM1078995///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: mucinous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tm_102///geo_accession: GSM1078996///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: mucinous///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tm_106///geo_accession: GSM1078997///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: mucinous///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tm_107///geo_accession: GSM1078998///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: mucinous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tm_110///geo_accession: GSM1078999///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: mucinous///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tm_95///geo_accession: GSM1079000///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: mucinous///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tm_96///geo_accession: GSM1079001///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: mucinous///characteristics_ch1.2: advanced disease stage: stage II///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tm_97///geo_accession: GSM1079002///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: mucinous///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Tm_98///geo_accession: GSM1079003///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: mucinous///characteristics_ch1.2: advanced disease stage: stage II///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_11///geo_accession: GSM1079004///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_14///geo_accession: GSM1079005///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_15///geo_accession: GSM1079006///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_17///geo_accession: GSM1079007///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage I///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_19///geo_accession: GSM1079008///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_20///geo_accession: GSM1079009///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_21///geo_accession: GSM1079010///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_23///geo_accession: GSM1079011///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_24///geo_accession: GSM1079012///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_26///geo_accession: GSM1079013///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_28///geo_accession: GSM1079014///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_2///geo_accession: GSM1079015///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_31///geo_accession: GSM1079016///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_32///geo_accession: GSM1079017///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_34///geo_accession: GSM1079018///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_35///geo_accession: GSM1079019///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_36///geo_accession: GSM1079020///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_37///geo_accession: GSM1079021///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_39///geo_accession: GSM1079022///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_3///geo_accession: GSM1079023///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_41///geo_accession: GSM1079024///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_43///geo_accession: GSM1079025///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage II///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_45///geo_accession: GSM1079026///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage IV///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_46///geo_accession: GSM1079027///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage II///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_47///geo_accession: GSM1079028///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: non-recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_4///geo_accession: GSM1079029///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_5///geo_accession: GSM1079030///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage IV///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: death///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 title: Ts_8///geo_accession: GSM1079031///status: Public on Jan 01 2014///submission_date: Feb 06 2013///last_update_date: Jan 01 2014///type: RNA///channel_count: 1///source_name_ch1: primary surgical treatment///organism_ch1: Homo sapiens///characteristics_ch1: tissue: ovarian cancer cells///characteristics_ch1.1: tissue subtype: serous///characteristics_ch1.2: advanced disease stage: stage III///characteristics_ch1.3: recurrence status: recurrence///characteristics_ch1.4: survival/death: survival///treatment_protocol_ch1: Frozen rissues///growth_protocol_ch1: Frozen tissue samples were embedded, and sections were cut and mounted on slides. The slides were stained with H&E to ensure that at least 70 1 duplicates: Length Class Mode 60 character character
An expression set