mds {Pigengene} | R Documentation

## MDS gene expression profile

### Description

Gene expression profile of 164 myelodysplastic syndromes (MDS) cases from Mills et al. study. The profile was compared with the profile of 202 acute myeloid leukemia (AML) cases and only the 1000 most differentially expressed genes are included.

### Usage

    data("mds")

### Format

A numeric matrix

### Details

The columns and rows are named according to the genes Entrez, and patient IDs, respectively. The original data was produced using Affymetrix Human Genome U133 Plus 2.0 Miccoaray.Mills et al. study is part of the MILE Study (Microarray Innovations In LEukemia) program, and aimed at prediction of AML transformation in MDS.

### Value

It is a `164*1000` numeric matrix.

### Note

This profile includes data of the 25 chronic myelomonocytic leukemia (CMLL) cases that can have different expression signatures according to Mills et al.

### Source

http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE15061

### References

Mills, Ken I., et al. (2009). Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome. Blood 114.5: 1063-1072.

### See Also

`Pigengene-package`, `one.step.pigengene`, `aml`, `compute.pigengene`

### Examples

    library(pheatmap)
    data(mds)
    pheatmap(mds[,1:20],show_rownames=FALSE)

[Package Pigengene version 1.12.0 Index]